Nonoxidative Fungicidal Mechanisms of Mammalian Granulocytes: Demonstration of Components with Candidacidal Activity in Human, Rabbit, and Guinea Pig Leukocytes
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چکیده
منابع مشابه
Nonoxidative fungicidal mechanisms of mammalian granulocytes: demonstration of components with candidacidal activity in human, rabbit, and guinea pig leukocytes.
Granulocytes from the peripheral blood of normal subjects and a patient with hereditary myeloperoxidase deficiency were homogenized in 0.34 M sucrose. A granule-rich fraction, prepared by sedimentation at 27,000 x g for 20 min, contained components that killed C. parapsilosis in vitro. These were extractable with 0.01 M citric acid and were shown by micropreparative polyacrylamide electrophores...
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A Survey on the Gastrointestinal Parasites of Rabbit and Guinea Pig in a Laboratory Animal House
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Nicotinamide adenine dinucleotide glycohydrolase activity in guinea pig polymorphonuclear leukocytes.
An enzyme is present in extracts of guinea pig polymorphonuclear leukocytes which can catalyze the hydrolysis of pyridine nucleotides. The enzyme is equally active toward nicotinamide adenine dinucleotide (NAD) or NAD phosphate, has an acid pH optimum, and is inhibited by either nicotinamide or isonicotinic acid hydrazide. This enzyme might be involved in the regulation of the pyridine nucleoti...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1975
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.11.6.1226-1234.1975